Barrier Structure and Function Studies · Lab experiment

How alike are a mouse's blood-brain barrier and yours?

Paper: Distinct gene expression profiles in blood–brain barrier capillary endothelial cells between mice and humans
Miao et al. · Microvascular Research 2026 · doi.org/10.1016/j.mvr.2026.104933

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How alike are a mouse's blood-brain barrier and yours? In the cells of the blood-brain barrier, gene activity is largely shared. But 169 genes were more active in humans, and 386 in mice.

AI-assisted summary with an AI voice, not reviewed by the authors. Made from the paper under its CC BY licence. Read the paper before relying on a finding. Keywords: blood-brain barrier, capillary endothelial cells, species-specific gene expression, human-mouse comparison, solute carrier transporters, alpha2-macroglobulin.